CombiFlash NextGen 100

Flash Chromatography System for normal and reverse phase purifications at flow rates up to 100 mL/min and pressures up to 150 psi (10 bar).

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Budget Friendly Gets the Job Done

The CombiFlash® NextGen 100 offers flow rates up to 100 mL/min at operating pressures up to 150 psi (10 bar). This is an economical system is designed to perform both normal and reverse phase purifications. 

The system accepts a variety of collection racks sizes so that purified compounds can be collected in volumes appropriate for the column size being used.

The Focus Gradient Generator feature, which provides predictive method development, is now included with Teledyne ISCO’s PeakTrak® software for the CombiFlash NextGen. This feature enables a user to select the target peak for purification from the results of a preset gradient run. It then quickly generates an optimized gradient method focused around that peak. Learn More >

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NextGen 100

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Solvent Miscibility Chart​​​

Setting the Standard in Flash Chromatography Performance

​Save Time, Save Space
  • Flow rates from 1 to 100 mL/min
  • Operating pressure up to 150 psi (10 bar) 
  • Wider Dynamic Range UV Detector
  • Improved baseline correction supports use of absorbing solvents
  • Faster processing with streamlined user interface
Photo Diode Array ​Detection​
  • UV and UV-Vis detectors use PDA technology
  • Display spectra in real time or post-run
  • Collect based on purity indicators​
Internal Vapor Sensor
  • Automatically stop the system if vapors are detected (level is user-configurable) for safe operation
Mass Dire​cted Purification
  • Collect only those peaks matching the mass of your compound
  • Eliminate the need for further analysis—save time in post-purification processing​
Integrated ELSD to Collect Non-Ch​romophoric Non​-Volatile Compounds
  • Integrated into the CombiFlash: No additional system footprint
  • All parameters programmed based on the solvent used or optimize operating conditions for your separation
  • Offers scalability and sensitivity for a wide sample load range​
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Foc​us Gradient Generator

​I​mproved Resolution is​ One Touch Away!

Save time and solvent while increasing col​umn loading. The Focus Gradient Generator for flash delivers optimized, predictive preparative method development using the results of a scouting run more quickly and efficiently than TLC. The Focus Gradient Generator in the CombiFlash® NextGen system makes calculations fas​​t and easy, eliminating the need to run multiple TLCs with different mobile phase concentrations. When combined with a PurIon™ mass spectrometer, you actually know which peak represents your compound of int​erest to optimize the method around — no guessing which spot is the target material.

Easy as 1, 2, 3​​​

graph with random peaks
Scouting Run
graph focused on peaks
Focused Run

Focus Gradient Generator paired with the PurIon mass spectrometer

Easy to Use Meth​​od Optimization Right the First Time!

No more guessing which peak is your compound! Coupling a scouting run with MS data means you can now have confidence that the separation is optimized for your target compound. Getting things done right the first time, saves money, solvent and most importantly time.​​

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Use of Focus Gradient Generator and PurIon MS to determine a purification method from a 4 g to a 40 g column.​​​​

Accessories

NextGen and PurIon
NextGen and PurIon

PurIon Mass-Directed Flash Chromatography

Verify before you purify!

The PurIon Mass Spectrometer is fully integrated with Teledyne ISCO’s PeakTrak® software. The ability to manually inject samples prior to purification and collection based on mass(es), makes this mass-directed NextGen system ideal for many applications.

  • Using the Method Development screen, easily adjust loading and ionization settings before committing your valuable sample for purification.
  • Use IonFinder to easily pick out more abundant MSadducts of your unique compounds.
  • Use “Terminate on Target” to shorten your separation after your desired mass is detected to save solvent and time.
  • Collect on up to six masses or five masses and a mass range.
Learn More >

RediSep® Flash Columns

A flash chromatography system, no matter the quality, needs superior columns to perform its best. That’s what you get with Teledyne LABS RediSep Flash Columns. Designed for high-capacity purification, RediSep columns are precision-packed for high resolution and reproducibility. They feature a one-piece design with no cumbersome or expensive adapters, valves, barrels, or other accessories. Luer end-fittings provide quick, easy connection to CombiFlash® systems You’ll enjoy fast, easy purification and scale-up from milligrams to tens of grams with RediSep Flash columns.

View the Selection
group of various columns
vapor hood

Vapor Enclosure for bench use outside of a fume hood

benchtop evaporator

Ecodyst rotary evaporators Evaporation closely follows chromatography in the purification process, and the Teledyne LABS and Ecodyst pairing are a perfect match.

Specifications

​Flow Rate Range1 - 100 mL/min
Pressure Limit​150 psi (10 bar)
Column Sizes4 - 330 g
Sample Size10 mg - 10 g
User Interface​12 in touchscreen (30.5 cm)
Dimensions (HxWxD)​26 x 14.1 x 17 in (66 x 36 x 43 cm)

​For a full list of product specifications, see the ​​Data​​sheet​​

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